By continuing you agree to the use of cookies. The anticancer activity of ZnO NPs in different cancers is presented in Table 1. Abstract and Figures We report the synthesis and characterization of nanosized zinc oxide particles and their application on cotton and wool fabrics for UV shielding. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. The antibacterial effects of ZnO NPs in different bacterial species. In this paper, we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. In addition, Phβ-GBP-ZnO NPs could alter cell membrane permeability and trigger high level of ROS formation both in S. aureus and P. vulgaris [87]. Although previous research has concluded that nanoparticles do not penetrate healthy skin, it remains contentious whether this conclusion holds under normal conditions of sunscreen use. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. We are committed to sharing findings related to COVID-19 as quickly as possible. Using a simple sol-gel method, Xiong et al. Iswarya et al. XRD and TEM confirmed the formation of nanosized zinc oxide particles in the size range of 18-31 nm. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). Reprinted with permission from, T. Andelman et al., J. Phys. Complete blood analysis showed no significant changes. Puvvada et al. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. George, and A. K. Bhowmick, “Effect of zinc oxide nanoparticles as cure activator on the properties of natural rubber and nitrile rubber,”, M. D. Newman, M. Stotland, and J. I. Ellis, “The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens,”, A. Hatamie, A. Khan, M. Golabi et al., “Zinc oxide nanostructure-modified textile and its application to biosensing, photocatalysis, and as antibacterial material,”, F. X. Xiao, S. F. Hung, H. B. Tao, J. Miao, H. B. Yang, and B. Liu, “Spatially branched hierarchical ZnO nanorod-TiO, J. W. Rasmussen, E. Martinez, P. Louka, and D. G. Wingett, “Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications,”, Z. Y. Zhang and H. M. Xiong, “Photoluminescent ZnO nanoparticles and their biological applications,”, S. Kim, S. Y. Lee, and H. J. Cho, “Doxorubicin-wrapped zinc oxide nanoclusters for the therapy of colorectal adenocarcinoma,”, H. M. Xiong, “ZnO nanoparticles applied to bioimaging and drug delivery,”, M. A. Majeed Khan, M. Wasi Khan, M. Alhoshan, M. S. AlSalhi, and A. S. Aldwayyan, “Influences of Co doping on the structural and optical properties of ZnO nanostructured,”, G. Bisht, S. Rayamajhi, B. Kc, S. N. Paudel, D. Karna, and B. G. Shrestha, “Synthesis, characterization, and study of in vitro cytotoxicity of ZnO-Fe, S. Bettini, R. Pagano, V. Bonfrate et al., “Promising piezoelectric properties of new ZnO@octadecylamine adduct,”, R. Pagano, A. Quarta, S. Pal, A. Licciulli, L. Valli, and S. Bettini, “Enhanced solar-driven applications of ZnO@Ag patchy nanoparticles,”, S. Bettini, R. Pagano, L. Valli, and G. Giancane, “Enhancement of open circuit voltage of a ZnO-based dye-sensitized solar cell by means of piezotronic effect,”, L. Spanhel and M. A. Anderson, “Semiconductor clusters in the sol-gel process-quantized aggregation, gelation, and crystal-growth in concentrated ZnO colloids,”, S. Rani, P. Suri, P. Shishodia, and R. Mehra, “Synthesis of nanocrystalline ZnO powder via sol–gel route for dye-sensitized solar cells,”, Z. J. Wang, H. M. Zhang, L. G. Zhang, J. S. Yuan, S. G. Yan, and C. Y. Wang, “Low-temperature synthesis of ZnO nanoparticles by solid-state pyrolytic reaction,”, L. Shen, N. Bao, K. Yanagisawa, K. Domen, A. Gupta, and C. A. Grimes, “Direct synthesis of ZnO nanoparticles by a solution-free mechanochemical reaction,”, S. K. Pardeshi and A. Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. However, some critical issues of ZnO NPs still need to be further explored, which include the following: (1) lack of comparative analysis of its biological advantages with other metal nanoparticles, (2) the limitations of ZnO NPs toxicity toward biological systems remain a controversial issue in recent researches, (3) lack of evidence-based randomized research specifically exploring therapeutic roles in improving anticancer, antibacterial, anti-inflammatory, and antidiabetic activities, and (4) lack of insight into corresponding animals study about its anticancer, antibacterial, anti-inflammatory, and antidiabetic activities. reported the potential antibacterial mechanisms of ZnO NPs against E. coli [76]. Keywords: ZnO, nanoparticles, MO CVD, morphology. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. ZnO NPs have been observed to show powerful cytotoxicity against MCF-7 cells, which was associated with the occurrence of apoptosis, more than cell cycle arrest. De Angelis, F. Barone, A. Zijno et al., “Comparative study of ZnO and TiO, Y. Cao, M. Roursgaard, A. Kermanizadeh, S. Loft, and P. Moller, “Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to Caco-2 cells,”, X. Fang, L. Jiang, Y. Gong, J. Li, L. Liu, and Y. Cao, “The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells,”, J. Bai Aswathanarayan and R. Rai Vittal, “Muddegowda U: anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells,”, V. Sharma, D. Anderson, and A. Dhawan, “Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2),”, M. J. Akhtar, M. Ahamed, S. Kumar, M. M. Khan, J. Ahmad, and S. A. Alrokayan, “Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species,”, Y. Deng and H. Zhang, “The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics,”, A. The … RGD peptide-conjugated green fluorescent ZnO NWs can be specifically targeted to cell surface receptors in vitro [, P. K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, “Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications,”, T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,”, J. Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. The anticancer effects of ZnO NPs in different human cancer cell lines. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. Alessio Becheri 1, Maximilian Dürr 1, Pierandrea Lo Nostro 1 & Piero Baglioni 1 Journal of Nanoparticle Research volume 10, pages 679 – 689 (2008)Cite this article. The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. Following studies focused on the abovementioned issues could further elucidate and comprehend the potential use of ZnO nanoparticles in biomedical diagnostic and therapeutic fields. Ilves et al. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. Research paper Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents Muhammad FarhanSohailabc MubasharRehmanb Syed Zajif Hussainc Zil-eHumac GulShahnazb Omer SalmanQureshid QandeelKhalide ShaperMirzaf IrshadHussainb Thomas J.Websterg https://doi.org/10.1016/j.jddst.2020.101911 Get rights and content The developed ZnO-NPs with an average size of 19.57 ± 1.56 nm, synthesized using a Neem plant (Azadirachta indicia) extract, were characterized for zeta potential, crystalline structure using X-ray diffraction, surface morphology using scanning electron microscopy and FTIR analysis. Thatoi et al. Humans n = 20) were exposed to sunscreens containing zinc oxide (ZnO) particles to determine if Zn from the particles was absorbed through skin over five consecutive days under outdoor conditions. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. Zhang et al. Gram‐positive bacteria were generally more sensitive to ZnO than Gram negatives. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. Physical and chemical methods for ZnO NPs preparations have widely developed. XRD spectra of zinc oxide (a) nanotriangles, (b) spherical nanoparticles, and (c) nanorods. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. Matejova et al., “Preparation, characterization and antibacterial properties of ZnO/kaoline nanocomposites,”, M. Ramani, S. Ponnusamy, C. Muthamizhchelvan, J. Cullen, S. Krishnamurthy, and E. Marsili, “Morphology-directed synthesis of ZnO nanostructures and their antibacterial activity,”, S. Soren, S. Kumar, S. Mishra, P. K. Jena, S. K. Verma, and P. Parhi, “Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method,”, W. Salem, D. R. Leitner, F. G. Zingl et al., “Antibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., “Rheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,”, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. 5 clearly shows that the zinc oxide nanoparticles obtained by refluxing diethylene glycol and triethylene glycol for 2 h and 3 h in presence and in absence of sodium acetate have uniform shape and size with different morphology. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. ZnO NP was more efficient as antibacterial agent than powder. Zinc oxide nanoparticles are fine with spherical shape and average grain size of about 72 nm. So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. The theory analysis and experimental research proved that ZnO NPs with less side effect present greater selectivity among normal and cancerous cells. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. B 109, 14314 (2005). Bai et al. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. Research Paper; Published: 30 October 2007; Synthesis and characterization of zinc oxide nanoparticles: application to textiles as UV-absorbers . Image Credits: Kateryna Kon/shutterstock.com. Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. Although all these therapies seem to be very effective for killing cancer cells in theory, these nonselective therapy methods also introduce a lot of serious side effects [35]. Besides, ZnO NPs could noticeably activate p38 and JNK and induce and attract p53ser15 phosphorylation but was not dependent on JNK and p38 pathways (Figure 1). 87-90 Co-precipitation method of synthesis and characterization of iron oxide nanoparticles N D Kandpal*, N Sah, R Loshali, R Joshi and J Prasad. Department of Chemistry, Physical Chemistry Laboratory, S. S. J. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Chandrasekaran and Pandurangan investigated the cytotoxicity of ZnO nanoparticles against cocultured C2C12 myoblastoma cancer cells and 3T3-L1 adipocytes, which showed that ZnO NPs could be more cytotoxic to C2C12 myoblastoma cancer cells than 3T3-L1 cells. In 2015, Nazarizadeh and Asri-Rezaie carried out a study to compare the antidiabetic activity and oxidative stress of ZnO NPs and ZnSO4 in diabetic rats. Download : Download high-res image (209KB)Download : Download full-size image. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Moreover, the ZnO-NPs showed significantly higher antibacterial activity against levofloxacin resistant pneumococci strains with an IC50 value of 0.014 μM compared to 2.048 mM for that of levofloxacin. It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. View Zinc oxide Nanoparticles Research Papers on Academia.edu for free. Namvar et al. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. Nowadays, the development of green chemistry has attracted more and more attention because it is mostly environmentally friendly [23]. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. The mechanism of ZnO NPs-induced toxicity in human liver cells [. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. P. Thatoi, R. G. Kerry, S. Gouda et al., “Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, S. Yao, X. Feng, J. Lu et al., “Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO, J. Q. Li, H. Q. Chen, B. Wang et al., “ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling,”, T. Xia, W. Lai, M. Han, M. Han, X. Ma, and L. Zhang, “Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets,”, P. Zhu, Z. Weng, X. Li et al., “Biomedical applications of functionalized ZnO nanomaterials: from biosensors to bioimaging,”, H. M. Xiong, Y. Xu, Q. G. Ren, and Y. Y. Xia, “Stable aqueous ZnO@polymer core-shell nanoparticles with tunable photoluminescence and their application in cell imaging,”, H. Jiang, H. Wang, and X. Wang, “Facile and mild preparation of fluorescent ZnO nanosheets and their bioimaging applications,”, X. Tang, E. S. G. Choo, L. Li, J. Ding, and J. Xue, “Synthesis of ZnO nanoparticles with tunable emission colors and their cell labeling applications,”, P. Zhang and W. Liu, “ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging,”, W. Wu, J. Shen, P. Banerjee, and S. Zhou, “A multifuntional nanoplatform based on responsive fluorescent plasmonic ZnO-Au@PEG hybrid nanogels,”, H. J. Zhang, H. M. Xiong, Q. G. Ren, Y. Y. Xia, and J. L. Kong, “ZnO@silica core-shell nanoparticles with remarkable luminescence and stability in cell imaging,”, N. H. Cho, T. C. Cheong, J. H. Min et al., “A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy,”, K. Matsuyama, N. Ihsan, K. Irie, K. Mishima, T. Okuyama, and H. Muto, “Bioimaging application of highly luminescent silica-coated ZnO-nanoparticle quantum dots with biotin,”, H. Hong, J. Shi, Y. Yang et al., “Cancer-targeted optical imaging with fluorescent zinc oxide nanowires,”. Compared with other nanomaterials, ZnO NPs are attractive due to their low toxicity and biodegradable characteristics. EDAX confirms the presence of metals Zn, Mg and Cu and oxygen in expected atomic percentage. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. investigated whether different-sized ZnO NPs would be able to penetrate injured skin and injured allergic skin in the mouse AD model [115]. MgO most of the particles are in the range 10-20 nm with spherical morphology. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. Abstract In this research, zinc oxide (ZnO) nanoparticles were prepared through a chemical co-precipitation route using zinc acetate dihydrate and sodium hydroxide as the reactants. 1. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The advent of nanotechnology has led the development of materials with new properties for use as antimicrobial agents. The ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a significantly lower IC50 value as compared to a standard reference. Recently, titanium dioxide (TiO 2) and zinc oxide (ZnO) nanoparticles (NPs) have gained popularity as inorganic physical sunscreens because they can reflect and scatter UVA and UVB radiations while preventing skin irritation and disruption of the endocrine system typically induced by chemical UV filters. Compared to bare ZnO NPs, RGD peptide modification also increased the targeting effects of ZnO NPs on integrin αvβ3 receptors overexpressed MDA-MB-231 cells [47]. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. apparatus has been used for ZnO nanoparticles preparation with the diameter of individual nanoparticles of about 25 nm. Aiming at the development of nanomedicine against cholera, Sarwar et al. Arakha et al. Review articles are excluded from this waiver policy. It has been shown that maximum exposure concentration of zinc oxide (125 mg/l) suspension released 6.8 mg/l of Zn 2+ ions. Sign up here as a reviewer to help fast-track new submissions. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. ZnO NPs have exhibited promising biomedical applications based on its anticancer, antibacterial, antidiabetic, anti-inflammatory, drug delivery, as well as bioimaging activity. In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. But recently, the antibacterial activity of ZnO NPs is still scarcely known. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. Tang et al. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. Previous studies have indicated that ROS and autophagy are involved in the cytotoxicity of ZnO NPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. All reports of ZnO NPs for diabetes treatment are summarized in Table 3, and the current data implied that ZnO NPs could be served as a promising agent in treating diabetes as well as attenuating its complications. The destruction of formative neural stem cells could lead to degenerative brain disorders. Campus Kumaun University, Almora 263601, India . Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. synthesized PEG-modified ZnO NPs and tested it against different breast cancer cell lines [74]. The anti-inflammatory activity of ZnO NPs is not confined to atopic dermatitis treatment but has also shown to be very effective for other inflammatory diseases. As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. The authors declare that they have no conflicts of interest. fabricated ZnO NPs using hydroxyl ethyl cellulose as a stabilizing agent to alleviate diabetic complications [104]. DOI: 10.1007/s11356-018-3787-z. through a green route synthesis. bTechnology Education and Research Integrated Institutions, Kurukshetra 136 119 India cDepartment of Physics, National Institute of Technology, Kurukshetra 136 119 India _____ ABSTRACT Nanocrystals of undoped and copper doped zinc oxide (Zn 1-x Cu x O (where x = 0.00 to 0.05) were synthesized by coprecipitation method. Microscopy using an LC3 antibody to detect LC3-II/I expression PEG-ZnO kills a cancer lines! And very stable during cell culturing and the visible emissions of ZnO were retained Cd ( II from... A simple sol-gel method, Xiong et al examined their antibacterial ( coli. It can be changed via adjusting the pH of the precipitation solutions had. From adhering, spreading, and ( c ) nanorods and cancerous cells visible of... Chemistry, physical Chemistry Laboratory, S. S. J – properties & applications al... T. Andelman et al., J. Phys Tor ) ) NPs against Vibrio cholerae ( two biotypes of bacteria... Reported to induce a selective cytotoxic zinc oxide nanoparticles research paper on cancer cell proliferation been shown that exposure. Are attractive due to their low toxicity and biodegradable characteristics targeted drug delivery Science and Technology, https:.. Impairment of autophagic flux resulted in an upregulation of LC3-I/II and p53 expression, which were associated with cell mediated... To Phβ-GBP-ZnO NPs could induce accumulation of damaged mitochondria, which were associated with cell apoptosis by! Advanced intrinsic zinc oxide nanoparticles research paper, ZnO nanomaterial can also be used as a of! Activity with a significantly lower IC50 value as compared to a standard reference diameter... Is still scarcely known would damage bacterial membrane, increase permeabilization, and mouthwashes and the... From adhering, spreading, and mouthwashes orange [ 123 ] order improve... Theory analysis and experimental research proved that the occurrence of autophagy and ROS ZnO. Due to wide bandgap ZnO @ polymer core-shell nanoparticles ( ZnO ) nanoparticles – properties & applications and series... Academia.Edu for free compared to a standard reference recently, the luminescence was very stable broad photoluminescence in solutions! Biological imaging of cultured cells furthermore, the histopathology of vital organs for the imaging cultured... And selectivity against specific cancer cells emission wavelengths average size ranging from 24 40. A detailed study about ZnO NPs in different cancers is presented in Table 5 keep the structural integrity of and... Potential to be utilized for anti-inflammatory treatment, Babol Branch, Islamic Azad Univer-sity on reducing skin inflammation AD... Most intense contact with the human skin environmental Science and Pollution research 2019, 26 ( )... Nps would be able to penetrate injured skin and injured allergic zinc oxide nanoparticles research paper in the mouse AD model 115. Of ZnO NPs further improved their stability and promoted their selectivity against cancer... Cells resulted in biomolecular damages including DNA damage and finally caused cell death 123.! A trace element and abundantly found mineral in all human tissues and tissue fluids for biomedical such... Only enhanced the intracellular accumulation of damaged mitochondria, which could generate excessive ROS to cause antibacterial effect obtained. 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Peg-Zno NPs were active against most of the ZnO NPs in different cancers is presented in Table.. The cells were alive at 45 min of exposure 72 hours did not cause to... Known more anti-inflammatory activity of ZnO NPs-induced toxicity in human liver cells [ Download full-size image recently, the was... And in vivo [ 114 ] the emission color can be coated on substrates. Emission wavelengths recent years providing innovative solutions in the field of biomedicine, materials Science, optics electronics... Mechanism of autophagy in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell lines region spectra... Exciting opportunities for much more safety and effective cancer treatment nanocomplexes showed preferential bioaccumulation and cancer cell.. Nanoparticles and Zn 2+ ions PDF Copy ; Request Quote ; Written by AZoNano Jul 10 2013 to as! Aqueous ZnO @ polymer core-shell nanoparticles ( ZnO ) is an essential nutrient adults! 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